Thank you for taking the time to think about, and to comment on, my extravagant ideas. My initial reactions to your comments (which are very persuasive to me) is that the project itself, if pursued conscientiously is labor intensive enough, and the financial rewards are so marginal, that the bureaucratic obstacles make it not worth the struggle. Besides, the "peers" who would review and approve any application are so deeply committed to the status quo, that they would be prejudiced against my ideas and seek to scuttle them. I've been there, done that. ======================================================= As I contemplate the situation in which _you_ find yourself I am reminded of the "research" project from which I launched my surgical practice. When I finished the residency, there was available for my use a slit lamp camera, and it occurred to me that I might obtain useful information about the evolution of cataracts by obtaining serial photographs over a period of months. I didn't learn much about cataract development, but in the course of my efforts, I established relationships to several patients who, when it came time for surgery, thought that since I had taken the photographs of their cataracts, I should be the one to do the operation. In the light of this experience, my worms eye view of dialysis nephrology suggests to me that if I were DCI I would take the government up on its offers to fund "prevention" research in a big way, - by organizing prospective studies on nephrology patients, - some of whom might already be on dialysis elsewhere, - advertising for patients, "inducing" them to participate in these studies with generous payments from Federal funds, - of course with Federal blessing. Human nature being what it is, participants in such research, especially if they were treated courteously, would identify with DCI (and NEMC), would populate your dialysis clinics and become your patients.