Dear Marion, Thank you for your letter. The Irritable Bowel Syndrome study which you related seems to me to display various interesting and important facets which I neglected to mention. The significance of the distinction between "syndrome" as a coincidence of symptoms, and a "disease" as a phenomenon with an "organic" i.e. defined anatomic, biochemical, micro- biological "etiology" (causation). Secondly, the investigator's prejudice that sugar pills were "inert" even though they had been shown to have documented therapeutic effects. Fundamental to this prejudice is the irrational belief that the effectiveness of medication is contingent on a definable biochemical process. Thirdly, the travesty, the patent shallowness of the "physician- patient" relationship, where the "physicians" were investigators and the "patients" were experimental subjects recruited by advertisements and rewarded by the attention paid to their "functional" disorders. Fourth, the naive and unrealistic assumption implicit in the design of the study, that patients "understand" the information that is provided them, on the basis of which they are then to give "informed consent." Utter misconception of what it means "to know". In my own practice I've experimented - and observed - that patients' responses depend not at all on the logical "meaning" of the communication, but on the affect with which it is presented to them. From my perspective it's not just "American medicine", but "Western" medicine in its entirety which has been overwhelmed by technology and is trapped in an impenetrable thicket of logical misconceptions, "scientific" superstition, and spiritual depravity. As I may have written you before: our culture has an apparent need for an enemy within, - for diseases to be "conquered", and death to be "fought" to the bitter end, a need quite analogous to the need for imaginary foreign enemies whose specter is forever tempting the nation to destroy itself - and humanity. You write: _ "Your mention of scepticism as a threat to belief _ has made me wonder whether this wasn't a big issue _ in your childhood. Wasn't Religious Belief very _ important to your parents? I would think that _ persuading you of the importance of Religious Belief _ would have loomed large for them. Had you shown _ scepticism toward religious doctrine, I imagine _ this would have caused great consternation. _ But apparently that's not what happened. How come?" You misunderstood. I admit, I was too cryptic. The "belief" which I deemed threatened by "scepticism" is the mental certainty that the world and the person (myself) who inhabits that world are reliable and real. In other words, I contemplated scepticism as an hypothetical threat to sanity. I acknowledge that for the utterly religious mind, the realities of religious dogma and secular experience might overlap, if not indeed coincide. However our families, - and our culture - are so far removed from religious zeal that the matter barely seems worth even a passing thought. The sort of "Religious Belief" to which I think you refer was scorned by both my father and my mother, in his and her own way. My mother's adored grandfather August Roessner was an agnostic who refused to go to church and whose irreligiosity was denounced in Pastor Eisenberg's sermon on the occasion of Grossvater's funeral. In Germany, my mother used her church affiliation as protective camouflage against Nazi antisemitism. In Virginia, my mother found adherence to church rituals and rites indispensable instruments of assimilation to a culture from which she remained alienated until at the end she was overcome with senility. My father's religious experience was essential to him, but was at the same time uncompromisingly individual and inward. It was nothing that he would ever have tried to communicate or to "share". He subscribed most eloquently to our grandfather's motto, borrowed from Frederick the Great of Prussia: In meinem Staate soll jeder nach seiner Facon selig werden. (In my state, each person shall achieve salvation in his own fashion.) In this perspective it was not Onkel Heinz, but Onkel Fritz who proved - with his intolerance - to be renegade to the family tradition. Jochen