Dear Marion, A comment about communication - among ourselves or between physician and patient. The Vienna Circle's (Wiener Kreis - Moritz Schlick) concept of "protocol sentence" is highly relevant. The date, the hour and the minute, the price attached to a transaction, weight, temperature are examples of "facts" (symbolic data) which are unequivocal and which, barring misunderstanding will receive identical interpretations from the parties to the communication. Usually, however, ambiguity is difficult to avoid. E.g. the place name Harvard Square may be interpreted as a pointer to Massachusetts Avenue, or to Boylston Street, or to Brattle Street, - or to none or to all of these. Surveyors take great pains to identify exact locations. Many terms, for example diagnoses, may have a specific definition but a penumbra of applications so diffuse that in a given case the meaning must be determined by induction from a spectrum of symptoms and signs. It is a rare patient who is sufficiently intelligent and sensitive to understand and to accept the uncertainties and ambiguities of language. Much damage is done to patients by physicians who consider themselves obliged and able to tell their patients "The Truth." I frequently find myself in the position of being required to give a patient a certain item of "information"; but I have become quite proficient in neutralizing the misunderstanding by explaining in what sense I believe the required information to be misleading or untrue. I frequently explain to patients about given facts that I am ignorant of them and/or that they are inherently unknowable. The uncertainty principles of statistics that I recently mentioned seem to me relevant to much medical "knowledge" that is peddled as being "true." Jochen