Dear Marion, As I reread our most recent correspondence, I notice that I neglected to take the opportunity to comment, expand, pontificate about the issues you raised concerning Hippocratic medicine in general, as well as Hippocratic epistemology and Hippocratic ethics in particular. By way of introduction, I would point out that my philological experience with the Hippocrartic writings is very limited. I have read only fragments of what has been published and translated, and of these fragments I've latched onto what seems of special interest and significance to me. I've neglected to accept responsibility for even trying to ascertain to what extent the phrases that I extol, and the notions I distill from them, are in fact representative of the entire corpus. Subject to that caveat, I see no harm in trying to untangle the threads of my ideas and subject to the disclaimer of historical authenticity, use them to weave a new fabric. My hypothesis is that the theories which were impugned by by Hippocratic physicians were Pythagorean mathematics schemes which derived a spurious plausibility from intrinsic esthetic and or logical qualities, schemes that were proposed to be engrafted onto medical diagnosis and therapy in the absence of all empirical justification. A modern analogy might cite diagnosis or treatment by the criteria of astrology. In my own medical practice, I've been impressed by the importance of listening to the patient, of examining the patient and of experiencing vicariously the details of this particular patient's medical, social, and psychic history in the context of my clinical experience with other patients and in the context of what I have learned from books, periodicals and lectures. I remember with embarrassment the "clinical conferences" in which the treatment of patients desperately ill with glaucoma was determined by ballot, by the votes of inexperienced physicians who had memorized and internalized textbook wisdom, but who had never conversed with, never examined and never perused the medical records of the human being whose future they were then adjudicating with self-satisfied glibness. I was poignantly aware, even at the time, that the true purpose of these conferences was not to winnow the most effective treatment from competing possibilities, but to establish a social consensus which would appear to justify the selected course of action that was more likely than not destined ultimately to fail. Of course the modern physician must rely on second hand information that comes from beyond his own experience. Often this information will be inconsistent or contradictory, and the optimal course of action will be obscure. I review in my own mind the diagnoses and therapies which in the course of my sixty years of exposure to medical lore have been promoted as essential truth, only to fall into disfavor and to be abandoned years later. Is it rational to assume that each new day we step across a threshold which separates an admittedly faulty past froma perfect present and an equally perfect future? In some instances I remember even now my scepticism and incredulity at stupidity of the moment. I'm also much aware of the mistakes I myself have made, albeit in good faith and with the best of intentions. It is extraordinarily difficult to confront ones ignorance in more than a perfunctory manner. Consider that the successful physician's most important function is to create and to maintain the patients' confidence in his competence. The pressure to pretend that one knows what one cannot know is irresistable. It's only when I have retired, or almost retired from practice, that I can contemplate the range and depth of what I don't know. In the wake of this confession, I'm sure you won't want me for your ophthalmologist. Jochen