Dear Marion, Our letters crossing in the mail gives me a welcome opportunity to write yet again. I forwarded your letter to Klemens who has had much occasion to think about the effect of intravenous contrast media on the kidneys. There is also the issue of altered sensitivity to intravenous dye in the context of CLL. Before extending your elbow for the injection, ask your hematologist, ask the radiologist, maybe even ask Google. As always, my interest in medical problems is disproportionate to my relative lack of knowledge and experience. From this and previous letters, I infer a number of possibly unrelated questions. As you read my comments, please keep my ignorance in mind. 1 CLL 2. dyspnea 3. ?sleep apnea 4. ?adult asthma 5. ?albuterol inhaler 6. ?steroid inhaler 7. ?disease of the aorta 8. ?risk of flying 9. ?risk of acute medical problem while in France 2. Distinguish between a) shortness of breath which is only uncomfortable and makes you anxious, but does not impair physical funtions, - this I would NOT treat with an inhaler, and b) shortness of breath which severely limits your activity, i.e. keeps you from walking, from climbing stairs, from lying flat in bed, - this I would try to treat with an albuterol inhaler, or with oral medication other than steroid. It's my belief that the only risk of short term steroid inhaler use is lowering resistance to incipient infection such as pneumonia, but that continued use of a steroid inhaler may cause (or unmask) open angle glaucoma - usually but not always reversible on cessation of steroid use, and will if used long enough cause cataract formation. Eye surgeons are not interested in preseventing cataracts. They want to operate on them. It seems likely to me that protracted use of a steroid inhaler may also unmask (or cause) Type 2 diabetes. In any event, the inhaled steroid, while it affects the respiratory tract most directly, is also absorbed and affects other parts of the body. Into my evaluation of the pulmonologist's advice, I would factor his failure to acknowledge the risk of inhaled steroids. 3. The examinations for sleep apnea are not dangerous, neither is the treatment. However, it's my impression that the diagnosis is (sophisticated) guesswork. My approach would be "empirical". If there's suggestion of sleep apnea, why not get the positive pressure breathing apparatus. If using it makes you feel better, the diagnosis is confirmed; if it seems not to be worth the trouble, the diagnosis is in doubt. 4. Not having seen or heard you wheeze, I reserve judgment about your having asthma. The significance of asthma might be its being caused by avoidable allergens. I would be open minded and observant. 7. About a CT scan for possible aortic disease, I would be conservative, not only because of possible toxicity of the dye, but because of the unknown effect of a substantial amount of radiation on CLL. The amount of radiation delivered in the course of CT scan is substantial. While high dose radiation is used to treat accumulations of lymphocytes e.g. in the spleen, it seems possible that low dose radiation might stimulate lymphocyte production. At minimum I'd ask the hematologist. I would also have the existing X-rays evaluated by one or more radiologists for advice concerning the benefits of additional imaging at this time. 8. The airlines have much experience with passengers who have respiratory impairment. I would find out whether one must arrange for supplemental oxygen prior to departure, or whether, if needed, it would be available in flight. Since you have had only episodes of mild shortness of breath, the risk of a life-threatening attack of asthma in flight seems to me to be small, - but I don't know. 9. One of the reasons Margaret and I no longer travel abroad is concern about being incapacitated - and hospitalized and trapped - by acute illness in a foreign culture. I'm not suggesting you should scrap your visit to France, - on the contrary, I think you should go; but if I put myself in your place, I would want to have some idea to whom I would turn for help and advice if overtaken by sudden, severe illness, - and of course about the adequacy of medical insurance coverage. Jochen