Dear Marion, Thank you very much for your letter. I'm much appreciative of your thoughtful analysis of theories and their validation. I'm often acutely aware of and embarrassed by my lack of specific knowledge and experience. In the wake of the discussion about fact vs. theory, I'm much impressed by the etymology of the word fact from the Latin factum, deed, powerfully corroborated as it is by the German word for fact: Tatsache (deed-matter). I conclude that my action - what I do, was ich tue, is the most compelling and accessible expression of subjectivity, a phenomenon which proves ultimately to be impermeable to any theory or to any verbal description. I am reminded, in this context of Goethe having Faust translate the opening verse of the Gospel of St. John, "In the beginning was the word" (where in the original, "word" is "logos") with "Im Anfang war die Tat", explicitly assigning primacy to action (fact) rather than to words (concepts, theories), perhaps corroborating Kierkegaard's assertion that subjectivity (action?) is truth. I admit that with my analysis I may be carrying semantics too far. Thank you also for sending the article about human stem cells modified to develop into retinal pigment epithelial cells and injected into human patients with macular disease. Reading and rereading this article makes me feel both ignorant and humble. Such bold experimentation is obviously vulnerable to criticism from many perspectives; but what came most immediately to my mind was the need to avoid the stance of Goethe's Mephistopheles who characterized himself with the words: "Ich bin der Geist der stets verneint." Maybe I should put aside the irresponsible writing in which I indulge, to try to become familiar with, and even proficient in the complex technology involved to be able to form my own constructive opinions, even though I would have no opportunity to implement or to apply them. Meanwhile, I will try to proceed with what I have been doing, my writing, as best I can. Good night. Jochen