The circumstance that the removal of a (donor) kidney results in 
a 10 fold increase the life-time incidence of ESRD, suggests to
me that the development of ESRD is a recursive exponential process, 
and that in asymptomatic and apparently healthy individuals, 
ESRD might hypothetically be at least partially preventable 
if early innocuous pharmacological, dietary or other life-style 
intervention were triggered by "borderline" but statistically 
significant "abnormal" laboratory findings.