DECISION THEORY In the days when patients still had to wait three months for an appointment with their ophthalmologist, it was fashionable to contemplate a style of practice where one assistant should take the patient's history, another assistant measure his acuity and perform the refraction, and yet a third assistant measure the tension, obtain the visual fields, perhaps photograph the fundus, and possibly obtain tonography, leaving to the ophthalmologist himself the visual examinations, with the slit lamp, the ophthalmoscope and the gonioscope, but above all reserving to the ophthalmologist as to a mini-god, the prerogative and responsibility of making the necessary decisions. It was unwittingly a quasi Aristotelian division of labor, with the physician as it were, possessing the knowledge of the first principles, and being at the same time the prime mover of the processes by which the patient was to be healed, and except in the case of surgical operation, leaving the execution of his instructions to his subordinates. The making of the decision and the surgical technique, it appears, are the two essentials, and in glaucoma practice, where so much of the treatment is non-surgical, the role of the ophthalmologist as decision-maker looms all the more important. Given then, the importance ascribed to the decision-making process, it seemes reasonable, inspired with the Aristotelian animus, to take a closer look, to ascertain if perhaps one might not, by investigating the principles of decision making, come to understand a bit better what one was trying to do. For many years I puzzled over these problems, aware that the eagerness to make decisions reflects decision-making as the badge of power in a rationalized society. This is the case not only in medicine, but in all the other professions, in business as well as in government. But while everyone is busy making decisions, hardly anyone concerns himself with the decision-making process, a discussion of which would appear to lead on the one hand into some of the most sterile realms of mathematics, but in the other direction, into an undisciplined rummaging about in words which unavoidably have different shades of meaning for different listeners. Thus, compliant with the dictates of conventional wisdom, I refrained from reflecting on decision-making while fulfilling my role of decision-maker as assiduously as ever. That is how things stood when, one day, two or three years ago, there came to my office a patient whose problem inadvertently shed light on the decision-making process. It was before the days of laser photocoagulation of the trabecular meshwork for open angle glaucoma that I was asked to see in consultation a memorable case. He was the last patient of the afternoon, a distiguished looking man with sparse white hair, which was neatly combed backwards, framing his low, weather-beaten forehead. His eyes, one of which was apparently already badly scarred from surgery, were - 2 - partially hidden under epicanthal folds which gave them an aura of knowing and mystery. In reply to my question as to what I might do for him, he handed me a packet of medical record sheets, and added softly, "I need to decide for myself." He spoke these words with a faint foreign accent, and as I listened, I wondered to myself what it was that he really meant. "May I look at these?" I asked. "Of course," he replied, "that is why I am here," and as I began to leaf through the sheaf of papers that he had brought me, he fixed his gaze on some undefined point in space. From the record it appeared that his glaucoma, then already far advanced, had been discovered on a routine eye examination 7 years previously, when he was sixty-five. Medication had brought the pressure only to the mid twenties. A filtering operation to the right eye had been decided upon and performed. Apparently a functioning filtering scar had been obtained, but cataract developed, and three years later, that is four years prior to the present visit, cataract extraction had been performed from below. Following this second operation, the filtering bleb had scarred, and the pressure had risen to the mid thirties. Six months after the cataract extraction, a trabeculectomy had been performed, but it too had been only transiently successful, because soon thereafter, echothiophate was prescribed, without any noticable effect on the pressure. A cyclodialysis had proved futile. Cryotherapy, performed only 9 months previously, had finally succeeded in reducing the pressure to the mid twenties, but with its performance, central vision had been lost, and to judge from the impressionistic field charts in the file, only a peripheral temporal field of variable dimensions remained. The left, the fellow eye was recorded as registering pressures between 20 and 25, and the left visual field showed both upper and lower Bjerrum scotomata that seemed to have been enlarging over the past several months. After I had finished looking over the records, I examined his eyes. I explained that my findings corroborated what his previous doctors had determined, and I discussed the surgical options that remained if one wished to try to preserve the remaining vision in either eye. "You mean to say," he began slowly and deliberately, having listened to my exposition, "that you think it might be worthwhile to perform more surgery on the right eye?" "Possibly," I said. "And the left eye?" he asked. "So far as I can infer from - 3 - the records that you bring me," I began cautiously, "it appears that the visual field in the left eye is gradually becoming smaller. The pressure in the left eye is not as low as it should be. If an operation could reduce the pressure in the left eye to a sufficiently low level, then it is likely that the vision in the left eye might be preserved in its present state. But from your experience with the right eye," I added, "you know that this is not always the case." "What do you think I should do?" "It is a decision for you to make. I wish I could make it for you, but I can't." He made no answer. Now, I thought in my vanity, he will say, I want you to do the operations that are necessary. That is why I have come. And then, I thought to myself, if the vision is not preserved, it will become my task to help him adjust to his blindness. "You must feel free to ask any questions you like," and I added as an afterthought, "I cannot promise that I will be able to answer them." He remained silent, and then I thought I saw that his heavy lids drew apart, and a faint smile, like a wreath of hope, began to encircle his lips. "I apologize to you," he said. "I see no reason for apology," I encouraged him, "It is a difficult decision, and sometimes it takes time to make up ones mind." "My apology," he began, "concerns not my apparent inability to make up my mind. I owe you an apology because I have troubled you for a decision, which I understand now, as I sit here, and observe your appropriating to your thoughts the history of my illness, is likely to prove a misunderstanding." The foreign accent to his words had reappeared. It occurred to me that he probably spoke many languages and was trying to express himself in an idiom that I could understand. It was a strange explanation. No patient had ever told me anything even remotely comparable. "I am a ..." he began, and then corrected himself, "My eyes and I are veterans of decision-making, and the experience deprives us of some of the confidence we might otherwise have had. To presume to decide is but another way to say that you don't know. I play the Numbers Game. I decide which one to bet on, only because I don't know the winning number. If I knew the winning number, you can be sure that - 4 - I wouldn't be making any decisions about which number to bet on. Decisions are the fig leaves of ignorance." "I've been fishing out of Gloucester for many a year, and I can't recollect a single time that I 'decided' which course to take for port, provided I had a chart and a compass and knew my position. The only time I ever made a decision under those circumstances is when I was lost and didn't know where I was, or couldn't find the chart, or the compass was broke. If I knew what to do for my eyes, I would do it, its because you don't know, that you tell me that you have to decide, and you haven't got the guts for that, so you put it off on me and tell me it's my decision." I was at a loss for something to say, and it would have been better had I said nothing. Only later did I realize that I was, in fact, retreating to the protective circle of my colleagues, when I suggested, "perhaps you would like to come to one of our medical conferences, where you will have the benefit of the opinions of numerous doctors, not just myself. I would tell them about you, they would all take a look at your eye, they would discuss your particular case, and then they would take a vote, and you would know just how things stood with you." "I have been there," he said, and I though I heard a faint echo of triumph in his voice. "I have been there and they voted, 18 to 2 in favor of surgery, and look where it got me, although I wouldn't say that the doctors who said they wouldn't operate were right. They probably just didn't trust themselves. If I'd taken their advice, I probably wouldn't be any better off, but no worse either." I tried to think of some graceful way to end the consultation, but it was the patient who had the final word. He got up and reached for the wallet that he carried in his hip pocket. "Please talk to the secretary," I said, but he seemed not to hear me. He dug in it for a twenty-five cent piece which he held up to the light, and scrutinized for a moment with his good eye. "If it's heads," he declared, "I'll have the operation, but if it's tails, then, let's put it this way, then the eyes have suffered enough. And while I watched in disbelief, he flipped the coin high into the air, caught it, and laid it on the back of his hand. "Tails," he said. He got up, and I saw him shudder as if he were cold, even though the steam had just come up in the radiator and the room was comfortably warm. "Enough is enough," he declared. "No more surgery." He offered me the quarter, and when I made no motion to take it, he put it on my desk. "It's for you doc," he said, "that's how to make a decision." He picked up the bundle of - 5 - his medical records, and walked out. To attempt to give a comprehensive account of the logical, mathematical and psychological processes decision- making is to brave a quicksand of argumentation, which, if it were to have any expectation of success, would require a dissertation of such length as to exhaust the patience and interest of the reader. Nonetheless, the lessons that my patient taught me are well worth repeating, even though they must, unavoidably, remain incomplete. Decisions are difficult, and the first rule is not to make them unless you have to. Many decisions that one makes, of course, have so little practical import as hardly to deserve that name. One should not minimize the difficulty or hazard of making decisions that vitally affect the health and happiness of ones patient. To be eager to make decisions is as surely the mark of an immature clinician as it is the mark of an immature surgeon to want badly to operate. Making decisions in the treatment of glaucoma, as, I suppose, in any other area of significance, is an art, in some ways not unlike the art of surgery, which requires to be learned by diligent and careful and humble practice. There is no question but that the quality of the decision will vary from one ophthalmologist to the other, just as some of us are more skillful surgeons than others. But the quality of decision- making, like the quality of surgery, is not so much a matter of talent as of effort. It is ones ability to subordinate all other competing interests to satisfactory solution of that one, unavoidably unique particular problem, which leads in one case as in the other to the most constructive and fruitful application of ones efforts. It is obvious, as my patient had pointed out, that we become aware that we are making a decision, only when we are confronted with uncertainty, and, to simplify the discussion, it seems reasonable to discard the notion of possibly "unconscious" decisions, and to reserve the term "decision" for those crossroads of thought that we recognize when we arrive at them and which give us the occasion to articulate a considered choice between two or more alternatives. If the goal for which we aim is fixed, and let us assume, arguendo, that in the care of glaucoma patients, this goal is the preservation of the patient's sight, then the only uncertainties between which we have to decide are the means by which that goal might best be accomplished. Decision- making is all too often a poor substitute for knowledge, and better than forcing a difficult decision is to obtain more facts. It is, in my experience, very common that a proposed decision concerning, for example, the institution of medical treatment or the recommendation of surgical therapy, appears necessary solely for lack of some readily obtainable facet of knowledge. The question, for example, whether the patient requires medication because the pressure is too - 6 - high, can often be avoided by obtaining a few more measurements of the pressure, which might make it apparent that the pressure was indeed so high as to require treatment without any doubt, or that most of the time it was so low as to make treatment clearly superfluous. Or that a patient requires filtering surgery because he is losing field, when sufficiently frequent examinations of the field would show that the apparent increase in field loss was only illusory. The first rule, therefore, in decision-making in the treatment of glaucoma is to make sure that a decision is in fact required, to be certain that the marginal value of additional information about the patient's problem is sufficiently slight so as to make superfluous further efforts at obtaining historical or clinical data. If one considers clinical decision-making in the treatment of glaucoma at all closely, one cannot help but be impressed by the degree to which the decision proves to be a reflection of society's expectations. Before he obtains permission to exercise his judgment in this regard, the ophthalmologist is required to spend years in training. The litany upon the length of medical education is too familiar to bear repetition. In the course of all those years, he learns not only the "facts" about anatomy, physiology and pathology which will utltimately guide his judgment. He is also trained to observe in a special way, and not least important, his powers of judgment are constrained by the prevailing dogma. In consideration of all the forces that would tend to bring his decisions into conformity with those of his colleagues, one must wonder that there is, about decision-making, any originality at all. Indeed, the circumstance that this is so speaks most eloquently for the independence of the human spirit. Nonetheless, indoctrination and training do leave their marks, and when we evaluate the decisions that are made, by ourselves or by others, we would do well to consider from time to time, to what extent our minds are merely mirrors that reflect rules of thought that others have enunciated, that are socially acceptable, and that have been drilled into us during the course of our professional training. This adherence to patterns of thought that are essentially social, is reinforced by the patient's expectation of a uniformity of opinion and judgment among physicians. It is common enough to hear the statement that if one consults several doctors, one obtains a different opinion from each one, and this is anything other than a compliment to the doctor on his originality. Also, of course, we must be aware that our colleagues are looking over our shoulders, prepared to endorse the rightness of our actions even when these issue in catastrophe, and prepared to criticize our actions as unconventional, even when what we do is overtly successful in attaining the desired end. And if all these social constraints were insufficient, there are the lawyers, soaring like vultures upon the thermals of legal fantasy, ready to pounce and profit from the misfortune of doctor and - 7 - patient alike. In this context it might well be said explicitly that, closely examined, the standards of professional conduct that lawyers conjure up as it suits their purposes, are ex post facto contraptions that they fashion for the issue at hand. In consideration of the diverse social constraints upon our decision-making, it is not surprising that one should, from time to time, encounter their institutionalization. It is, for example, not unheard of, to invite patients to appear before a group of physicians, who are presented with the medical history, and are given the opportunity, usually perfunctory, to perform some fragment of the eye examination, who then, like jurors sitting upon a legal action, discuss the patient's problem that has been presented to them and take a vote as to the proper decision. Interestingly, when the societal forces upon decision-making are carried to such an extreme, it becomes apparent to what large extent, notwithstanding all social constraints under which it takes place, the making of decisions is an individual enterprise; and while group decisions such as I have described may protect the patient from some absurd eccentricity of an aberrant practitioner, they almost never provide the optimal solution. It is important to understand why this must be the case. Except in the trivial case of unthinking conformity, the individual who conforms his judgment to that of his social group does so through the mediation of ideas and concepts. The bond that holds together the members of a society is communication in mathematical symbols, or, more commonly, in words and sentences. What distinguishes the verbal from the mathematical symbol is that individual experience controls the meaning of the verbal symbol while individual experience is controlled by the symbolism of mathematics. What distinguishes the verbal from the mathematical symbol is that the meaning of the verbal symbol is controlled by individual experience. The meaning of the mathematical symbol, however, is rigorously defined, and men spend years in disciplining their mental processes to accord to the imperatives of the mathematical scheme. In mathematics it is not the experience which defines the symbol but the symbol which defines the experience. Considering now the members of this clinical jury, one sees that each of them attaches to the words and phrases that are exchanged between them a meaning slightly different, corresponding to his own unique experiences. It is not only that one person may be a more acute oberver than the next, but the logical fabric in which the patient's problem is defined may have to him also a different, call it more realistic, call it a more truthful meaning. And though one may argue ones way to a common definition of words, the judgmental processes by which propositions and - 8 - merits are weighed one against the other and inaccessible to control, so that, confronted with the same set of propositions, two clinicians may well, and often do, arrive at differing conclusions, and an individual who is sensitive and thoughtful and, in the technical sense, passionate about his judgment will very possibly arrive at different and superior decisions from those that evolve from an electoral decision-making process. On the scientific horizon there looms the theoretical possibility of clinical decision-making entirely independent of individual judgment. The mathematical algorithms for computerized decision-making have long since been invented, and the computers are ready to run. What stands in the way is the circumstance that much of the clinical data that enters into the decision, the appreance of the optic disc is a prime example, is itself the product of judgment, circumstance borne out by the fact that it is infrequently solely an issue of data interpretation, whether the disc is excavated or whether field loss is progressing, upon which the clinical decision hinges. If and when all the significant historical and clinical data that enter into the glaucoma decision can be reproduceably encoded into symbols, a new era of automatic decision-making may dawn. * * * * *

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